Melenovsky Lab | IKEM
Laboratory of Molecular and Experimental Cardiology
Publications
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Soluble guanylyl cyclase stimulators and activators: Promising drugs for the treatment of hypertension?
Gawrys O, Kala P, Sadowski J, Melenovský V, Sandner P, Červenka L.
Eur J Pharmacol. 2024 Dec 5;987:177175.
DOI: 10.1016/j.ejphar.2024.177175
PMID: 39645219 Free article.
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Transgenic rat with ubiquitous expression of angiotensin-(1-7)-producing fusion protein: A new tool to study the role of protective arm of the renin-angiotensin system in the pathophysiology of cardio-renal diseases.
Červenka L, Husková Z, Kikerlová S, Gawrys O, Vacková Š, Škaroupková P, Sadowski J, Miklovič M, Molnár M, Táborský M, Melenovský V, Bader M.
Hypertens Res. 2024 Nov 13. doi: 10.1038/s41440-024-01995-y.
DOI: 10.1038/s41440-024-01995-y
PMID: 39537982.
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Injury-induced myosin-specific tissue-resident memory T cells drive immune checkpoint inhibitor myocarditis.
Kalinoski H, Daoud A, Rusinkevich V, Jurčová I, Talor MV, Welsh RA, Hughes D, Zemanová K, Stříž I, Hooper JE, Kautzner J, Peichl P, Melenovský V, Won T, Čiháková D.
Proc Natl Acad Sci U S A. 2024 Oct 15;121(42):e2323052121.
PMID: 39378095.
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Integration of Patient Reported Quality-of-life Data into Risk Assessment in Heart Failure.
Sideris K, Zhang M, Wohlfahrt P, Siu AF, Shen J, Carter S, Kyriakopoulos CP, Taleb I, Wever-Pinzon O, Shah K, Selzman CH, Rodriguez-Correa C, Kapelios C, Brinker L, Alharethi R, Hess R, Drakos SG, Steinberg BA, Fang JC, Kfoury AG, Melenovský V, Greene T, Spertus J, Stehlík J.
J Card Fail. 2024 Sep 18:S1071-9164(24)00381-6.
DOI: 10.1016/j.cardfail.2024.08.083
PMID: 39299541.
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Characterization of a new model of chemotherapy-induced heart failure with reduced ejection fraction and nephrotic syndrome in Ren-2 transgenic rats.
Gawrys O, Jíchová Š, Miklovič M, Husková Z, Kikerlová S, Sadowski J, Kollárová P, Lenčová-Popelová O, Hošková L, Imig JD, Mazurová Y, Kolář F, Melenovský V, Štěrba M, Červenka L.
Hypertens Res. 2024 Nov;47(11):3126-3146.
DOI: 10.1038/s41440-024-01865-7
PMID: 39245782 Free PMC article.
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Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction.
Solomon SD, McMurray JJV, Vaduganathan M, Claggett B, Jhund PS, Desai AS, Henderson AD, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Abidin IZ, Alcocer-Gamba MA, Atherton JJ, Bauersachs J, Chang-Sheng M, Chiang CE, Chioncel O, Chopra V, Comin-Colet J, Filippatos G, Fonseca C, Gajos G, Goland S, Goncalvesova E, Kang S, Katova T, Kosiborod MN, Latkovskis G, Lee AP, Linssen GCM, Llamas-Esperón G, Mareev V, Martinez FA, Melenovský V, Merkely B, Nodari S, Petrie MC, Saldarriaga CI, Saraiva JFK, Sato N, Schou M, Sharma K, Troughton R, Udell JA, Ukkonen H, Vardeny O, Verma S, von Lewinski D, Voronkov L, Yilmaz MB, Zieroth S, Lay-Flurrie J, van Gameren I, Amarante F, Kolkhof P, Viswanathan P; FINEARTS-HF Committees and Investigators.
N Engl J Med. 2024 Oct 24;391(16):1475-1485.
PMID: 39225278 Clinical Trial.
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Inflammation in Obesity-Related HFpEF: The STEP-HFpEF Program.
Verma S, Petrie MC, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Shah SJ, Rönnbäck C, Abildstrøm SZ, Liisberg K, Wolf D, von Lewinski D, Lelonek M, Melenovsky V, Senni M, Kosiborod MN; STEP-HFpEF Trial Committees and Investigators.
J Am Coll Cardiol. 2024 Oct 22;84(17):1646-1662.
DOI: 10.1016/j.jacc.2024.08.028
PMID: 39217564 Free article. Clinical Trial.
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Dapagliflozin, peptide YY, and weight loss in heart failure with preserved ejection fraction.
Reddy YNV, Melenovsky V, Asokan AK, Haluzik M, Carter RE, Nair S, Jensen MD, Borlaug BA.
Eur Heart J. 2024 Oct 5;45(37):3889-3891.
DOI: 10.1093/eurheartj/ehae534
PMID: 39167062 No abstract available.
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Genotype is associated with left ventricular reverse remodelling and early events in recent-onset dilated cardiomyopathy.
Kubanek M, Binova J, Piherova L, Krebsova A, Kotrc M, Hartmannova H, Hodanova K, Musalkova D, Stranecky V, Palecek T, Chaloupka A, Grochova I, Krejci J, Petrkova J, Melenovsky V, Kmoch S, Kautzner J.
ESC Heart Fail. 2024 Dec;11(6):4127-4138.
DOI: 10.1002/ehf2.15009
PMID: 39129193 Free PMC article.
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Biomarker profiles associated with reverse ventricular remodelling in patients with heart failure and a reduced ejection fraction: Insights from the echocardiographic substudy of the VICTORIA trial.
Tromp J, Lam CSP, Alemayehu W, de Filippi CR, Melenovský V, Sliwa K, Lopatin Y, Arango JL, Bahit MC, Roessig L, O’Connor CM, Shah P, Westerhout CM, Voors AA, Pieske B, Armstrong PW; VICTORIA Study Group.
Eur J Heart Fail. 2024 Oct;26(10):2231-2239.
DOI: 10.1002/ejhf.3397
PMID: 39078607 Clinical Trial.
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Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction.
Solomon SD, McMurray JJV, Vaduganathan M, Claggett B, Jhund PS, Desai AS, Henderson AD, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Abidin IZ, Alcocer-Gamba MA, Atherton JJ, Bauersachs J, Chang-Sheng M, Chiang CE, Chioncel O, Chopra V, Comin-Colet J, Filippatos G, Fonseca C, Gajos G, Goland S, Goncalvesova E, Kang S, Katova T, Kosiborod MN, Latkovskis G, Lee AP, Linssen GCM, Llamas-Esperón G, Mareev V, Martinez FA, Melenovský V, Merkely B, Nodari S, Petrie MC, Saldarriaga CI, Saraiva JFK, Sato N, Schou M, Sharma K, Troughton R, Udell JA, Ukkonen H, Vardeny O, Verma S, von Lewinski D, Voronkov L, Yilmaz MB, Zieroth S, Lay-Flurrie J, van Gameren I, Amarante F, Kolkhof P, Viswanathan P; FINEARTS-HF Committees and Investigators.
N Engl J Med. 2024 Oct 24;391(16):1475-1485.
PMID: 39225278 Clinical Trial.
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Inflammation in Obesity-Related HFpEF: The STEP-HFpEF Program.
Verma S, Petrie MC, Borlaug BA, Butler J, Davies MJ, Kitzman DW, Shah SJ, Rönnbäck C, Abildstrøm SZ, Liisberg K, Wolf D, von Lewinski D, Lelonek M, Melenovsky V, Senni M, Kosiborod MN; STEP-HFpEF Trial Committees and Investigators.
J Am Coll Cardiol. 2024 Oct 22;84(17):1646-1662.
DOI: 10.1016/j.jacc.2024.08.028
PMID: 39217564 Free article. Clinical Trial.
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Dapagliflozin, peptide YY, and weight loss in heart failure with preserved ejection fraction.
Reddy YNV, Melenovsky V, Asokan AK, Haluzik M, Carter RE, Nair S, Jensen MD, Borlaug BA.
Eur Heart J. 2024 Oct 5;45(37):3889-3891.
DOI: 10.1093/eurheartj/ehae534
PMID: 39167062 No abstract available.
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Genotype is associated with left ventricular reverse remodelling and early events in recent-onset dilated cardiomyopathy.
Kubanek M, Binova J, Piherova L, Krebsova A, Kotrc M, Hartmannova H, Hodanova K, Musalkova D, Stranecky V, Palecek T, Chaloupka A, Grochova I, Krejci J, Petrkova J, Melenovsky V, Kmoch S, Kautzner J.
ESC Heart Fail. 2024 Dec;11(6):4127-4138.
DOI: 10.1002/ehf2.15009
PMID: 39129193 Free PMC article.
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Biomarker profiles associated with reverse ventricular remodelling in patients with heart failure and a reduced ejection fraction: Insights from the echocardiographic substudy of the VICTORIA trial.
Tromp J, Lam CSP, Alemayehu W, de Filippi CR, Melenovsky V, Sliwa K, Lopatin Y, Arango JL, Bahit MC, Roessig L, O’Connor CM, Shah P, Westerhout CM, Voors AA, Pieske B, Armstrong PW; VICTORIA Study Group.
Eur J Heart Fail. 2024 Oct;26(10):2231-2239.
DOI: 10.1002/ejhf.3397
PMID: 39078607 Clinical Trial.
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A Prospective Randomized Trial of Direct Oral Anticoagulant Therapy With a Fully Magnetically Levitated LVAD: The DOT-HM3 Study.
Netuka I, Tucanova Z, Ivak P, Gregor S, Kolesar DM, Marek T, Melenovsky V, Binova J, Dorazilova Z, Hegarova M, Podolec M, Riha H, Connors JM, Mehra MR.
Circulation. 2024 Aug 6;150(6):509-511.
DOI: 10.1161/CIRCULATIONAHA.124.069726
PMID: 38594972 Clinical Trial. No abstract available.
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Semaglutide in Patients with Obesity-Related Heart Failure and Type 2 Diabetes.
Kosiborod MN, Petrie MC, Borlaug BA, Butler J, Davies MJ, Hovingh GK, Kitzman DW, Møller DV, Treppendahl MB, Verma S, Jensen TJ, Liisberg K, Lindegaard ML, Abhayaratna W, Ahmed FZ, Ben-Gal T, Chopra V, Ezekowitz JA, Fu M, Ito H, Lelonek M, Melenovský V, Merkely B, Núñez J, Perna E, Schou M, Senni M, Sharma K, van der Meer P, Von Lewinski D, Wolf D, Shah SJ; STEP-HFpEF DM Trial Committees and Investigators.
N Engl J Med. 2024 Apr 18;390(15):1394-1407.
PMID: 38587233 Clinical Trial.
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Comparing Plasma Donor-derived Cell-free DNA to Gene Expression in Endomyocardial Biopsies in the Trifecta-Heart Study.
Halloran PF, Reeve J, Mackova M, Madill-Thomsen KS, Demko Z, Olymbios M, Campbell P, Melenovsky V, Gong T, Hall S, Stehlik J.
Transplantation. 2024 Sep 1;108(9):1931-1942.
DOI: 10.1097/TP.0000000000004986
PMID: 38538559 Free PMC article.
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Redefining the molecular rejection states in 3230 heart transplant biopsies: Relationships to parenchymal injury and graft survival.
Halloran PF, Madill-Thomsen K, Aliabadi-Zuckermann AZ, Cadeiras M, Crespo-Leiro MG, Depasquale EC, Deng M, Gökler J, Hall S, Jamil A, Kim DH, Kobashigawa J, Macdonald P, Melenovsky V, Patel J, Potena L, Shah K, Stehlik J, Zuckermann A.
Am J Transplant. 2024 Aug;24(8):1414-1426.
DOI: 10.1016/j.ajt.2024.03.031
PMID: 38527588 Free article.
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Development and validation of a prognostic score integrating remote heart failure symptoms and clinical variables in mortality risk prediction after myocardial infarction: the PragueMi score.
Wohlfahrt P, Jenča D, Melenovský V, Stehlik J, Mrázková J, Šramko M, Kotrč M, Želízko M, Adámková V, Piťha J, Kautzner J.
Eur J Prev Cardiol. 2024 Oct 10;31(14):1713-1720.
PMID: 38497201
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Acetylsalicylic acid use and development of cardiac allograft vasculopathy: A national prospective study using highly automated 3-D optical coherence tomography analysis.
Mayerova L, Wohlfahrt P, Sonka M, Chen Z, Kautzner J, Melenovsky V, Karmazin V, Malek I, Bedanova H, Tomasek A, Ozabalova E, Krejci J, Kovarnik T, Pazdernik M.
Clin Transplant. 2024 Mar;38(3):e15275.
DOI: 10.1111/ctr.15275
PMID: 38477134
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Renal denervation improves cardiac function independently of afterload and restores myocardial norepinephrine levels in a rodent heart failure model.
Miklovič M, Gawryś O, Honetschlägerová Z, Kala P, Husková Z, Kikerlová S, Vaňourková Z, Jíchová Š, Kvasilová A, Kitamoto M, Maxová H, Puertas-Frias G, Mráček T, Sedmera D, Melenovský V.
Hypertens Res. 2024 Oct;47(10):2718-2730.
DOI: 10.1038/s41440-024-01580-3
PMID: 38302774 Free PMC article.
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The impact of phosphodiesterase-5 inhibition or angiotensin-converting enzyme inhibition on right and left ventricular remodeling in heart failure due to chronic volume overload.
Tykvartova T, Miklovic M, Kotrc M, Skaroupkova P, Kazdova L, Trnovska J, Skop V, Kolar M, Novotny J, Melenovsky V.
Pharmacol Res Perspect. 2024 Feb;12(1):e1172.
DOI: 10.1002/prp2.1172
PMID: 38284173 Free PMC article.
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Pressure overload is associated with right ventricular dyssynchrony in heart failure with reduced ejection fraction.
Monzo L, Tupy M, Borlaug BA, Reichenbach A, Jurcova I, Benes J, Mlateckova L, Ters J, Kautzner J, Melenovsky V.
ESC Heart Fail. 2024 Apr;11(2):1097-1109.
DOI: 10.1002/ehf2.14682
PMID: 38263857 Free PMC article.
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Remote Heart Failure Symptoms Assessment After Myocardial Infarction Identifies Patients at Risk for Death.
Wohlfahrt P, Jenča D, Melenovský V, Stehlik J, Spertus JA, Mrázková J, Šramko M, Kotrč M, Želízko M, Adámková V, Piťha J, Kautzner J.
J Am Heart Assoc. 2024 Jan 16;13(2):e032505.
PMID: 38193321 Free PMC article.
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Atrial fibrillation therapy and stroke prevention in hemodialysis patients.
Melenovský V, Osmančík P.
Kardiol Pol. 2023;81(12):1193-1204.
DOI: 10.33963/v.kp.98424
PMID: 38189503 Free article.
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Erratum to ‘Acute Effect of Atrial Fibrillation on Circulating Natriuretic Peptides: The Influence of Heart Rate, Rhythm Irregularity, and Left Atrial Pressure Overload’.
Stojadinović P, Wichterle D, Fukunaga M, Peichl P, Melenovský V, Franeková J, Kautzner J, Šramko M.
Am J Cardiol. 2024 Feb 1;212:144.
DOI: 10.1016/j.amjcard.2023.12.022
PMID: 38134969 No abstract available.
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Effects of Semaglutide on Symptoms, Function, and Quality of Life in Patients With Heart Failure With Preserved Ejection Fraction and Obesity: A Prespecified Analysis of the STEP-HFpEF Trial.
Kosiborod MN, Verma S, Borlaug BA, Butler J, Davies MJ, Jon Jensen T, Rasmussen S, Erlang Marstrand P, Petrie MC, Shah SJ, Ito H, Schou M, Melenovský V, Abhayaratna W, Kitzman DW; STEP-HFpEF Trial Committees and Investigators.
Circulation. 2024 Jan 16;149(3):204-216.
DOI: 10.1161/CIRCULATIONAHA.123.067505
PMID: 37952180 Free PMC article.
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Establishing a nationwide pediatric heart transplantation program with mid-term results comparable to worldwide data – The Czech experience.
Koubský K, Gebauer R, Poruban R, Vojtovič P, Materna O, Melenovský V, Hošková L, Netuka I, Burkert J, Janoušek J.
Pediatr Transplant. 2024 Feb;28(1):e14626.
DOI: 10.1111/petr.14626
PMID: 37853942
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Acute Effect of Atrial Fibrillation on Circulating Natriuretic Peptides: The Influence of Heart Rate, Rhythm Irregularity, and Left Atrial Pressure Overload.
Stojadinovic P, Wichterle D, Fukunaga M, Peichl P, Melenovský V, Franekova J, Kautzner J, Sramko M.
Am J Cardiol. 2023 Dec 1;208:156-163.
DOI: 10.1016/j.amjcard.2023.09.060
PMID: 37839172
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FGF-23 is a biomarker of RV dysfunction and congestion in patients with HFrEF.
Benes J, Kroupova K, Kotrc M, Petrak J, Jarolim P, Novosadova V, Kautzner J, Melenovsky V.
Sci Rep. 2023 Sep 25;13(1):16004.
DOI: 10.1038/s41598-023-42558-4
PMID: 37749114 Free PMC article.
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Semaglutide in HFpEF across obesity class and by body weight reduction: a prespecified analysis of the STEP-HFpEF trial.
Borlaug BA, Kitzman DW, Davies MJ, Rasmussen S, Barros E, Butler J, Einfeldt MN, Hovingh GK, Møller DV, Petrie MC, Shah SJ, Verma S, Abhayaratna W, Ahmed FZ, Chopra V, Ezekowitz J, Fu M, Ito H, Lelonek M, Melenovsky V, Núñez J, Perna E, Schou M, Senni M, van der Meer P, Von Lewinski D, Wolf D, Kosiborod MN.
Nat Med. 2023 Sep;29(9):2358-2365.
DOI: 10.1038/s41591-023-02526-x
PMID: 37635157 Free PMC article.
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Ferric Carboxymaltose in Heart Failure with Iron Deficiency.
Mentz RJ, Garg J, Rockhold FW, Butler J, De Pasquale CG, Ezekowitz JA, Lewis GD, O’Meara E, Ponikowski P, Troughton RW, Wong YW, She L, Harrington J, Adamczyk R, Blackman N, Hernandez AF; HEART-FID Investigators.
N Engl J Med. 2023 Sep 14;389(11):975-986.
PMID: 37632463 Clinical Trial.
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Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity.
Kosiborod MN, Abildstrøm SZ, Borlaug BA, Butler J, Rasmussen S, Davies M, Hovingh GK, Kitzman DW, Lindegaard ML, Møller DV, Shah SJ, Treppendahl MB, Verma S, Abhayaratna W, Ahmed FZ, Chopra V, Ezekowitz J, Fu M, Ito H, Lelonek M, Melenovský V, Merkely B, Núñez J, Perna E, Schou M, Senni M, Sharma K, Van der Meer P, von Lewinski D, Wolf D, Petrie MC; STEP-HFpEF Trial Committees and Investigators.
N Engl J Med. 2023 Sep 21;389(12):1069-1084.
PMID: 37622681 Clinical Trial.
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Right ventricular global dysfunction score: a new concept of right ventricular function assessment in patients with heart failure with reduced ejection fraction (HFrEF).
Benes J, Kotrc M, Wohlfahrt P, Kroupova K, Tupy M, Kautzner J, Melenovsky V.
Front Cardiovasc Med. 2023 Aug 4;10:1194174.
DOI: 10.3389/fcvm.2023.1194174
PMID: 37600032 Free PMC article.
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Simultaneous biventricular pressure-volume analysis in rats.
Miklovic M, Kala P, Melenovsky V.
J Physiol Pharmacol. 2023 Apr;74(2).
DOI: N/A
PMID: 37453090 Free article.
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The treatment with sGC stimulator improves survival of hypertensive rats in response to volume-overload induced by aorto-caval fistula.
Gawrys O, Husková Z, Škaroupková P, Honetschlägerová Z, Vaňourková Z, Kikerlová S, Melenovský V, Bačová BS, Sykora M, Táborský M, Červenka L.
Naunyn Schmiedebergs Arch Pharmacol. 2023 Dec;396(12):3757-3773.
DOI: 10.1007/s00210-023-02561-y
PMID: 37338578 Free PMC article.
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Effect of vericiguat on left ventricular structure and function in patients with heart failure with reduced ejection fraction: The VICTORIA echocardiographic substudy.
Pieske B, Pieske-Kraigher E, Lam CSP, Melenovský V, Sliwa K, Lopatin Y, Arango JL, Bahit MC, O’Connor CM, Patel MJ, Roessig L, Morris DA, Kropf M, Westerhout CM, Zheng Y, Armstrong PW; VICTORIA Study Group.
Eur J Heart Fail. 2023 Jul;25(7):1012-1021.
DOI: 10.1002/ejhf.2836
PMID: 36994634 Free article.
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Letter by Monzo and Melenovsky Regarding Article, “Metabolomic Profiling of the Effects of Dapagliflozin in Heart Failure With Reduced Ejection Fraction: DEFINE-HF”.
Monzo L, Melenovsky V.
Circulation. 2023 Mar 14;147(11):920-921.
DOI: 10.1161/CIRCULATIONAHA.122.061155
PMID: 36913496 No abstract available.
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Attenuation of Hypocretin/Orexin Signaling Is Associated With Increased Mortality After Myocardial Infarction.
Wohlfahrt P, Jenča D, Melenovský V, Jarolím P, Dlouhá D, Šramko M, Kotrč M, Želízko M, Mrázková J, Piťha J, Adámková V, Kautzner J.
J Am Heart Assoc. 2023 Mar 21;12(6):e028987.
PMID: 36892078 Free PMC article.
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Role of genetics in the development of cardiac allograft vasculopathy.
Mayerova L, Chaloupka A, Wohlfahrt P, Hubacek JA, Bedanova H, Chen Z, Kautzner J, Melenovsky V, Malek I, Tomasek A, Ozabalova E, Krejci J, Kovarnik T, Sonka M, Pazdernik M.
Bratisl Lek Listy. 2023;124(3):193-200.
DOI: 10.4149/BLL_2023_031
PMID: 36598310 Free PMC article.
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Trajectories and determinants of left ventricular ejection fraction after the first myocardial infarction in the current era of primary coronary interventions.
Wohlfahrt P, Jenča D, Melenovský V, Šramko M, Kotrč M, Želízko M, Mrázková J, Adámková V, Pitha J, Kautzner J.
Front Cardiovasc Med. 2022 Nov 14;9:1051995.
DOI: 10.3389/fcvm.2022.1051995
PMID: 36451922 Free PMC article.
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Metformin treatment is associated with improved outcome in patients with diabetes and advanced heart failure (HFrEF).
Benes J, Kotrc M, Kroupova K, Wohlfahrt P, Kovar J, Franekova J, Hegarova M, Hoskova L, Hoskova E, Pelikanova T, Jarolim P, Kautzner J, Melenovsky V.
Sci Rep. 2022 Jul 29;12(1):13038.
DOI: 10.1038/s41598-022-17327-4
PMID: 35906276 Free PMC article.
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Pulmonary Vasculature Responsiveness to Phosphodiesterase-5A Inhibition in Heart Failure With Reduced Ejection Fraction: Possible Role of Plasma Potassium.
Monzo L, Reichenbach A, Al-Hiti H, Jurcova I, Huskova Z, Kautzner J, Melenovsky V.
Front Cardiovasc Med. 2022 May 26;9:883911.
PMID: 35722098 Free PMC article.
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Vericiguat and Health-Related Quality of Life in Patients With Heart Failure With Reduced Ejection Fraction: Insights From the VICTORIA Trial.
Butler J, Stebbins A, Melenovsky V, Sweitzer NK, Cowie MR, Stehlik J, Khan MS, Blaustein RO, Ezekowitz JA, Hernandez AF, Lam CSP, Nkulikiyinka R, O’Connor CM, Pieske BM, Ponikowski P, Spertus JA, Voors AA, Anstrom KJ, Armstrong PW; VICTORIA Study Group.
Circ Heart Fail. 2022 Jun;15(6):e009337.
DOI: 10.1161/CIRCHEARTFAILURE.121.009337
PMID: 35656822 Clinical Trial.
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Heart failure-related quality-of-life impairment after myocardial infarction.
Wohlfahrt P, Jenča D, Stehlik J, Melenovsky V, Mrázková J, Staněk V, Kettner J, Šramko M, Želízko M, Adámková V, Piťha J, Kautzner J.
Clin Res Cardiol. 2023 Jan;112(1):39-48.
DOI: 10.1007/s00392-022-02008-z
PMID: 35304902
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Subclinical Pulmonary Congestion and Abnormal Hemodynamics in Heart Failure With Preserved Ejection Fraction.
Jain CC, Tschirren J, Reddy YNV, Melenovsky V, Redfield M, Borlaug BA.
JACC Cardiovasc Imaging. 2022 Apr;15(4):629-637.
DOI: 10.1016/j.jcmg.2021.09.017
PMID: 34801461 Free PMC article.
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Uncoupling between intravascular and distending pressures leads to underestimation of circulatory congestion in obesity.
Obokata M, Reddy YNV, Melenovsky V, Sorimachi H, Jarolim P, Borlaug BA.
Eur J Heart Fail. 2022 Feb;24(2):353-361.
DOI: 10.1002/ejhf.2377
PMID: 34755429 Free article.
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Effects of Trandolapril on Structural, Contractile and Electrophysiological Remodeling in Experimental Volume Overload Heart Failure.
Jarkovská D, Miklovič M, Švíglerová J, Červenka L, Škaroupková P, Melenovský V, Štengl M.
Front Pharmacol. 2021 Sep 10;12:729568.
DOI: 10.3389/fphar.2021.729568
PMID: 34566652 Free PMC article.
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2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure.
McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Böhm M, Burri H, Butler J, Čelutkienė J, Chioncel O, Cleland JGF, Coats AJS, Crespo-Leiro MG, Farmakis D, Gilard M, Heymans S, Hoes AW, Jaarsma T, Jankowska EA, Lainscak M, Lam CSP, Lyon AR, McMurray JJV, Mebazaa A, Mindham R, Muneretto C, Francesco Piepoli M, Price S, Rosano GMC, Ruschitzka F, Kathrine Skibelund A; ESC Scientific Document Group.
Eur Heart J. 2021 Sep 21;42(36):3599-3726.
DOI: 10.1093/eurheartj/ehab368
PMID: 34447992 Free article. No abstract available.
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Kidney Response to Chemotherapy-Induced Heart Failure: mRNA Analysis in Normotensive and Ren-2 Transgenic Hypertensive Rats.
Jíchová Š, Gawryś O, Kompanowska-Jezierska E, Sadowski J, Melenovský V, Hošková L, Červenka L, Kala P, Veselka J, Čertíková Chábová V.
Int J Mol Sci. 2021 Aug 6;22(16):8475.
DOI: 10.3390/ijms22168475
PMID: 34445179 Free PMC article.
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Hemoglobin and Clinical Outcomes in the Vericiguat Global Study in Patients With Heart Failure and Reduced Ejection Fraction (VICTORIA).
Ezekowitz JA, Zheng Y, Cohen-Solal A, Melenovský V, Escobedo J, Butler J, Hernandez AF, Lam CSP, O’Connor CM, Pieske B, Ponikowski P, Voors AA, deFilippi C, Westerhout CM, McMullan C, Roessig L, Armstrong PW.
Circulation. 2021 Nov 2;144(18):1489-1499.
DOI: 10.1161/CIRCULATIONAHA.121.056797
PMID: 34432985 Free article.
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Right versus left ventricular remodeling in heart failure due to chronic volume overload.
Havlenova T, Skaroupkova P, Miklovic M, Behounek M, Chmel M, Jarkovska D, Sviglerova J, Stengl M, Kolar M, Novotny J, Benes J, Cervenka L, Petrak J, Melenovsky V.
Sci Rep. 2021 Aug 24;11(1):17136.
DOI: 10.1038/s41598-021-96618-8
PMID: 34429479 Free PMC article.
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Trends in the treatment and survival of heart failure patients: a nationwide population-based study in the Czech Republic.
Táborský M, Skála T, Lazárová M, Aiglová R, Špinar J, Špinarová L, Vítovec J, Kautzner J, Melenovský V, Málek F, Dušek L, Jarkovský J, Benešová K, Vícha M, Linhart A.
ESC Heart Fail. 2021 Oct;8(5):3800-3808.
DOI: 10.1002/ehf2.13559
PMID: 34409755 Free PMC article.
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Salutary Acute Effects of Exercise on Central Hemodynamics in Heart Failure With Preserved Ejection Fraction.
Obokata M, Reddy YNV, Koepp KE, Stewart GM, Olson TP, Melenovsky V, Burkhoff D, Borlaug BA.
J Card Fail. 2021 Dec;27(12):1313-1320.
DOI: 10.1016/j.cardfail.2021.04.014
PMID: 33974969 Free PMC article.
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Very low lipoprotein(a) and increased mortality risk after myocardial infarction.
Wohlfahrt P, Jenča D, Melenovský V, Franeková J, Jabor A, Šramko M, Staněk V, Želízko M, Poledne R, Piťha J, Adámková V, Kautzner J.
Eur J Intern Med. 2021 Sep;91:33-39.
DOI: 10.1016/j.ejim.2021.04.012
PMID: 33972150
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Effects of renal sympathetic denervation on the course of congestive heart failure combined with chronic kidney disease: Insight from studies with fawn-hooded hypertensive rats with volume overload induced using aorto-caval fistula.
Honetschlagerová Z, Škaroupková P, Kikerlová S, Husková Z, Maxová H, Melenovský V, Kompanowska-Jezierska E, Sadowski J, Gawrys O, Kujal P, Červenka L, Čertíková Chábová V.
Clin Exp Hypertens. 2021 Aug 18;43(6):522-535.
DOI: 10.1080/10641963.2021.1907398
PMID: 33783285 Free article.
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Renal Sympathetic Denervation Attenuates Congestive Heart Failure in Angiotensin II-Dependent Hypertension: Studies with Ren-2 Transgenic Hypertensive Rats with Aortocaval Fistula.
Honetschlagerová Z, Gawrys O, Jíchová Š, Škaroupková P, Kikerlová S, Vaňourková Z, Husková Z, Melenovský V, Kompanowska-Jezierska E, Sadowski J, Kolář F, Novotný J, Hejnová L, Kujal P, Červenka L.
Kidney Blood Press Res. 2021;46(1):95-113.
DOI: 10.1159/000513071
PMID: 33530085 Free article.
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The effect of three major co-morbidities on quality of life and outcome of patients with heart failure with reduced ejection fraction.
Benes J, Kotrc M, Jarolim P, Hoskova L, Hegarova M, Dorazilova Z, Podzimkova M, Binova J, Lukasova M, Malek I, Franekova J, Jabor A, Kautzner J, Melenovsky V.
ESC Heart Fail. 2021 Apr;8(2):1417-1426.
DOI: 10.1002/ehf2.13227
PMID: 33512782 Free PMC article.
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[Expert consensus on the importance of iron deficiency and the possibility of its correction in patients with heart failure].
Melenovský V, Táborský M, Linhart A, Malík J, Málek F, Pudil R, Krejčí J, Šíranec M.
Vnitr Lek. 2021 Winter;67(8):495-497.
PMID: 35459371 Czech.
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Heart failure after myocardial infarction: incidence and predictors.
Jenča D, Melenovský V, Stehlik J, Staněk V, Kettner J, Kautzner J, Adámková V, Wohlfahrt P.
ESC Heart Fail. 2021 Feb;8(1):222-237.
DOI: 10.1002/ehf2.13144
PMID: 33319509 Free PMC article. Review.
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Deleterious Effects of Hyperactivity of the Renin-Angiotensin System and Hypertension on the Course of Chemotherapy-Induced Heart Failure after Doxorubicin Administration: A Study in Ren-2 Transgenic Rat.
Kala P, Bartušková H, Piťha J, Vaňourková Z, Kikerlová S, Jíchová Š, Melenovský V, Hošková L, Veselka J, Kompanowska-Jezierska E, Sadowski J, Gawrys O, Maxová H, Červenka L.
Int J Mol Sci. 2020 Dec 8;21(24):9337.
DOI: 10.3390/ijms21249337
PMID: 33302374 Free PMC article.
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Myocardial ketone body utilization in patients with heart failure: The impact of oral ketone ester.
Monzo L, Sedlacek K, Hromanikova K, Tomanova L, Borlaug BA, Jabor A, Kautzner J, Melenovsky V.
Metabolism. 2021 Feb;115:154452.
DOI: 10.1016/j.metabol.2020.154452
PMID: 33248064
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Acute Unloading Effects of Sildenafil Enhance Right Ventricular-Pulmonary Artery Coupling in Heart Failure.
Monzo L, Reichenbach A, Al-Hiti H, Borlaug BA, Havlenova T, Solar N, Tupy M, Ters J, Kautzner J, Melenovsky V.
J Card Fail. 2021 Feb;27(2):224-232.
DOI: 10.1016/j.cardfail.2020.11.007
PMID: 33232820
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Clinical Outcomes and Response to Vericiguat According to Index Heart Failure Event: Insights From the VICTORIA Trial.
Lam CSP, Giczewska A, Sliwa K, Edelmann F, Refsgaard J, Bocchi E, Ezekowitz JA, Hernandez AF, O’Connor CM, Roessig L, Patel MJ, Pieske B, Anstrom KJ, Armstrong PW; VICTORIA Study Group.
JAMA Cardiol. 2021 Jun 1;6(6):706-712.
DOI: 10.1001/jamacardio.2020.6455
PMID: 33185650 Free PMC article. Clinical Trial.
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Dysregulation of epicardial adipose tissue in cachexia due to heart failure: the role of natriuretic peptides and cardiolipin.
Janovska P, Melenovsky V, Svobodova M, Havlenova T, Kratochvilova H, Haluzik M, Hoskova E, Pelikanova T, Kautzner J, Monzo L, Jurcova I, Adamcova K, Lenkova L, Buresova J, Rossmeisl M, Kuda O, Cajka T, Kopecky J.
J Cachexia Sarcopenia Muscle. 2020 Dec;11(6):1614-1627.
DOI: 10.1002/jcsm.12631
PMID: 33084249 Free PMC article.
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Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis.
Pazdernik M, Bedanova H, Chen Z, Kautzner J, Melenovsky V, Malek I, Slavcev A, Bartonova M, Karmazin V, Eckhardt T, Tomasek A, Ozabalova E, Kovarnik T, Wohlfahrt P, Sonka M.
Transpl Immunol. 2021 Apr;65:101340.
DOI: 10.1016/j.trim.2020.101340
PMID: 33069814 Free PMC article.
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Exercise dynamics of cardiac biomarkers and hemoconcentration in patients with chronic systolic heart failure.
Benes J, Kotrc M, Conrad MJ, Kautzner J, Melenovsky V, Jarolim P.
J Card Fail. 2020 Dec;26(12):1100-1105.
DOI: 10.1016/j.cardfail.2020.07.004
PMID: 32687881 No abstract available.
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Danon disease is an underdiagnosed cause of advanced heart failure in young female patients: a LAMP2 flow cytometric study.
Gurka J, Piherova L, Majer F, Chaloupka A, Zakova D, Pelak O, Krebsova A, Peichl P, Krejci J, Freiberger T, Melenovsky V, Kautzner J, Kalina T, Sikora J, Kubanek M.
ESC Heart Fail. 2020 Oct;7(5):2534-2543.
DOI: 10.1002/ehf2.12823
PMID: 32657043 Free PMC article.
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Complete recovery of fulminant cytotoxic CD8 T-cell-mediated myocarditis after ECMELLA unloading and immunosuppression.
Jurcova I, Rocek J, Bracamonte-Baran W, Zelizko M, Netuka I, Maluskova J, Kautzner J, Cihakova D, Melenovsky V, Maly J.
ESC Heart Fail. 2020 Aug;7(4):1976-1981.
DOI: 10.1002/ehf2.12697
PMID: 32485066 Free PMC article.
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Desminopathy: Novel Desmin Variants, a New Cardiac Phenotype, and Further Evidence for Secondary Mitochondrial Dysfunction.
Kubanek M, Schimerová T, Piherová L, Brodehl A, Krebsová A, Ratnavadivel S, Stanasiuk C, Hansíková H, Zeman J, Paleček T, Houštěk J, Drahota Z, Nůsková H, Mikešová J, Zámečník J, Macek M Jr, Ridzoň P, Malusková J, Stránecký V, Melenovský V, Milting H, Kmoch S.
J Clin Med. 2020 Mar 29;9(4):937.
DOI: 10.3390/jcm9040937
PMID: 32235386 Free PMC article.
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Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction.
Armstrong PW, Pieske B, Anstrom KJ, Ezekowitz J, Hernandez AF, Butler J, Lam CSP, Ponikowski P, Voors AA, Jia G, McNulty SE, Patel MJ, Roessig L, Koglin J, O’Connor CM; VICTORIA Study Group.
N Engl J Med. 2020 May 14;382(20):1883-1893.
PMID: 32222134 Free article. Clinical Trial.
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How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).
Pieske B, Tschöpe C, de Boer RA, Fraser AG, Anker SD, Donal E, Edelmann F, Fu M, Guazzi M, Lam CSP, Lancellotti P, Melenovský V, Morris DA, Nagel E, Pieske-Kraigher E, Ponikowski P, Solomon SD, Vasan RS, Rutten FH, Voors AA, Ruschitzka F, Paulus WJ, Seferovic P, Filippatos G.
Eur J Heart Fail. 2020 Mar;22(3):391-412.
DOI: 10.1002/ejhf.1741
PMID: 32133741 Free article.
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Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis.
Choi HS, Won T, Hou X, Chen G, Bracamonte-Baran W, Talor MV, Jurčová I, Szárszoi O, Čurnova L, Stříž I, Hooper JE, Melenovský V, Čiháková D.
Cell Rep. 2020 Mar 3;30(9):2989-3003.e6.
DOI: 10.1016/j.celrep.2020.02.040
PMID: 32130902 Free PMC article.
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Heart rate and early progression of cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis.
Pazdernik M, Wichterle D, Chen Z, Bedanova H, Kautzner J, Melenovský V, Karmazin V, Malek I, Stiavnicky P, Tomasek A, Ozabalova E, Krejci J, Wahle A, Zhang H, Kovarnik T, Sonka M.
Clin Transplant. 2020 Feb;34(2):e13773.
DOI: 10.1111/ctr.13773
PMID: 31859379 Free PMC article.
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Baseline features of the VICTORIA (Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction) trial.
Pieske B, Patel MJ, Westerhout CM, Anstrom KJ, Butler J, Ezekowitz J, Hernandez AF, Koglin J, Lam CSP, Ponikowski P, Roessig L, Voors AA, O’Connor CM, Armstrong PW; VICTORIA Study Group.
Eur J Heart Fail. 2019 Dec;21(12):1596-1604.
DOI: 10.1002/ejhf.1664
PMID: 31820546 Free article.
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Baseline features of the VICTORIA (Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction) trial.
Pieske B, Patel MJ, Westerhout CM, Anstrom KJ, Butler J, Ezekowitz J, Hernandez AF, Koglin J, Lam CSP, Ponikowski P, Roessig L, Voors AA, O’Connor CM, Armstrong PW; VICTORIA Study Group.
Eur J Heart Fail. 2019 Dec;21(12):1596-1604.
DOI: 10.1002/ejhf.1664
PMID: 31820546 Free article. Clinical Trial.
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Noninvasive evaluation of pulmonary artery pressure during exercise: the importance of right atrial hypertension.
Obokata M, Kane GC, Sorimachi H, Reddy YNV, Olson TP, Egbe AC, Melenovsky V, Borlaug BA.
Eur Respir J. 2020 Feb 12;55(2):1901617.
DOI: 10.1183/13993003.01617-2019
PMID: 31771997 Free article.
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The haemodynamic basis of lung congestion during exercise in heart failure with preserved ejection fraction.
Reddy YNV, Obokata M, Wiley B, Koepp KE, Jorgenson CC, Egbe A, Melenovsky V, Carter RE, Borlaug BA.
Eur Heart J. 2019 Dec 1;40(45):3721-3730.
PMID: 31609443 Free PMC article. Clinical Trial.
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Clinical and Humoral Determinants of Congestion in Heart Failure: Potential Role of Adiponectin.
Monzo L, Kotrc M, Benes J, Sedlacek K, Jurcova I, Franekova J, Jarolim P, Kautzner J, Melenovsky V.
Kidney Blood Press Res. 2019;44(5):1271-1284.
DOI: 10.1159/000502975
PMID: 31553971 Free article.
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The neurohormonal basis of pulmonary hypertension in heart failure with preserved ejection fraction.
Obokata M, Kane GC, Reddy YNV, Melenovsky V, Olson TP, Jarolim P, Borlaug BA.
Eur Heart J. 2019 Dec 1;40(45):3707-3717.
PMID: 31513270 Free PMC article. Clinical Trial.
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How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).
Pieske B, Tschöpe C, de Boer RA, Fraser AG, Anker SD, Donal E, Edelmann F, Fu M, Guazzi M, Lam CSP, Lancellotti P, Melenovsky V, Morris DA, Nagel E, Pieske-Kraigher E, Ponikowski P, Solomon SD, Vasan RS, Rutten FH, Voors AA, Ruschitzka F, Paulus WJ, Seferovic P, Filippatos G.
Eur Heart J. 2019 Oct 21;40(40):3297-3317.
PMID: 31504452 Free article.
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Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction.
Solomon SD, McMurray JJV, Anand IS, Ge J, Lam CSP, Maggioni AP, Martinez F, Packer M, Pfeffer MA, Pieske B, Redfield MM, Rouleau JL, van Veldhuisen DJ, Zannad F, Zile MR, Desai AS, Claggett B, Jhund PS, Boytsov SA, Comin-Colet J, Cleland J, Düngen HD, Goncalvesova E, Katova T, Kerr Saraiva JF, Lelonek M, Merkely B, Senni M, Shah SJ, Zhou J, Rizkala AR, Gong J, Shi VC, Lefkowitz MP; PARAGON-HF Investigators and Committees.
N Engl J Med. 2019 Oct 24;381(17):1609-1620.
PMID: 31475794 Free article.
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Altered Renal Vascular Responsiveness to Vasoactive Agents in Rats with Angiotensin II-Dependent Hypertension and Congestive Heart Failure.
Vacková Š, Kikerlová S, Melenovsky V, Kolář F, Imig JD, Kompanowska-Jezierska E, Sadowski J, Červenka L.
Kidney Blood Press Res. 2019;44(4):792-809.
DOI: 10.1159/000501688
PMID: 31430751 Free PMC article.
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Intraventricular placement of a spring expander does not attenuate cardiac atrophy of the healthy heart induced by unloading via heterotopic heart transplantation.
Pokorný M, Mrázová I, Kubátová H, Piťha J, Malý J, Pirk J, Maxová H, Melenovský V, Šochman J, Sadowski J, Červenka L, Čermák Z, Volenec K, Netuka I.
Physiol Res. 2019 Aug 29;68(4):567-580.
DOI: 10.33549/physiolres.933936
PMID: 31177788 Free article.
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Mitochondrial Function, Skeletal Muscle Metabolism, and Iron Deficiency in Heart Failure.
van der Meer P, van der Wal HH, Melenovsky V.
Circulation. 2019 May 21;139(21):2399-2402.
DOI: 10.1161/CIRCULATIONAHA.119.040134
PMID: 31107619 No abstract available.
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The Role of GDF-15 in Heart Failure Patients With Chronic Kidney Disease.
Benes J, Kotrc M, Wohlfahrt P, Conrad MJ, Franekova J, Jabor A, Lupinek P, Kautzner J, Melenovsky V, Jarolim P.
Can J Cardiol. 2019 Apr;35(4):462-470.
DOI: 10.1016/j.cjca.2018.12.027
PMID: 30935637
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Coronary Artery Disease Is Associated with an Increased Amount of T Lymphocytes in Human Epicardial Adipose Tissue.
Mráz M, Cinkajzlová A, Kloučková J, Lacinová Z, Kratochvílová H, Lipš M, Pořízka M, Kopecký P, Pierzynová A, Kučera T, Melenovský V, Stříž I, Lindner J, Haluzík M.
Mediators Inflamm. 2019 Feb 7;2019:4075086.
DOI: 10.1155/2019/4075086
PMID: 30881222 Free PMC article.
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Pharmacological Blockade of Soluble Epoxide Hydrolase Attenuates the Progression of Congestive Heart Failure Combined With Chronic Kidney Disease: Insights From Studies With Fawn-Hooded Hypertensive Rats.
Vacková Š, Kopkan L, Kikerlová S, Husková Z, Sadowski J, Kompanowska-Jezierska E, Hammock BD, Imig JD, Táborský M, Melenovský V, Červenka L.
Front Pharmacol. 2019 Jan 23;10:18.
PMID: 30728778 Free PMC article.
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Myocardial iron homeostasis and hepcidin expression in a rat model of heart failure at different levels of dietary iron intake.
Petrak J, Havlenova T, Krijt M, Behounek M, Franekova J, Cervenka L, Pluhacek T, Vyoral D, Melenovsky V.
Biochim Biophys Acta Gen Subj. 2019 Apr;1863(4):703-713.
DOI: 10.1016/j.bbagen.2019.01.010
PMID: 30677469
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Deterioration in right ventricular structure and function over time in patients with heart failure and preserved ejection fraction.
Obokata M, Reddy YNV, Melenovsky V, Pislaru S, Borlaug BA.
Eur Heart J. 2019 Feb 21;40(8):689-697.
PMID: 30544228 Free PMC article.
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Skeletal Muscle Abnormalities and Iron Deficiency in Chronic Heart Failure: An Exercise 31P Magnetic Resonance Spectroscopy Study of Calf Muscle.
Melenovsky V, Hlavata K, Sedivy P, Dezortova M, Borlaug BA, Petrak J, Kautzner J, Hajek M.
Circ Heart Fail. 2018 Sep;11(9):e004800.
DOI: 10.1161/CIRCHEARTFAILURE.117.004800
PMID: 30354361
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Detection and quantitation of iron in ferritin, transferrin and labile iron pool (LIP) in cardiomyocytes using 55Fe and storage phosphorimaging.
Krijt M, Jirkovska A, Kabickova T, Melenovsky V, Petrak J, Vyoral D.
Biochim Biophys Acta Gen Subj. 2018 Dec;1862(12):2895-2901.
DOI: 10.1016/j.bbagen.2018.09.005
PMID: 30279145
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Quantitative 3D Analysis of Coronary Wall Morphology in Heart Transplant Patients: OCT-Assessed Cardiac Allograft Vasculopathy Progression.
Chen Z, Pazdernik M, Zhang H, Wahle A, Guo Z, Bedanova H, Kautzner J, Melenovsky V, Kovarnik T, Sonka M.
Med Image Anal. 2018 Dec;50:95-105.
DOI: 10.1016/j.media.2018.09.003
PMID: 30253306 Free PMC article.
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Kidney Response to Heart Failure: Proteomic Analysis of Cardiorenal Syndrome.
Melenovsky V, Cervenka L, Viklicky O, Franekova J, Havlenova T, Behounek M, Chmel M, Petrak J.
Kidney Blood Press Res. 2018;43(5):1437-1450.
DOI: 10.1159/000493657
PMID: 30235455 Free article.
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Protein-losing enteropathy in an adult with non-ischaemic cardiomyopathy: complete reversal by heart transplantation.
Melenovsky V, Kubanek M, Kacer P.
ESC Heart Fail. 2018 Oct;5(5):842-845.
DOI: 10.1002/ehf2.12342
PMID: 30051970 Free PMC article.
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Independent effect of atrial fibrillation on natriuretic peptide release.
Sramko M, Wichterle D, Melenovsky V, Franekova J, Clemens M, Fukunaga M, Kautzner J.
Clin Res Cardiol. 2019 Feb;108(2):142-149.
DOI: 10.1007/s00392-018-1332-1
PMID: 30051184
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Myocardial Injury and Cardiac Reserve in Patients With Heart Failure and Preserved Ejection Fraction.
Obokata M, Reddy YNV, Melenovsky V, Kane GC, Olson TP, Jarolim P, Borlaug BA.
J Am Coll Cardiol. 2018 Jul 3;72(1):29-40.
DOI: 10.1016/j.jacc.2018.04.039
PMID: 29957229 Free PMC article.
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Exercise unmasks distinct pathophysiologic features in heart failure with preserved ejection fraction and pulmonary vascular disease.
Gorter TM, Obokata M, Reddy YNV, Melenovsky V, Borlaug BA.
Eur Heart J. 2018 Aug 7;39(30):2825-2835.
PMID: 29947750 Free PMC article.
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Hemodynamic Correlates and Diagnostic Role of Cardiopulmonary Exercise Testing in Heart Failure With Preserved Ejection Fraction.
Reddy YNV, Olson TP, Obokata M, Melenovsky V, Borlaug BA.
JACC Heart Fail. 2018 Aug;6(8):665-675.
DOI: 10.1016/j.jchf.2018.03.003
PMID: 29803552 Free PMC article.
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Haemodynamics, dyspnoea, and pulmonary reserve in heart failure with preserved ejection fraction.
Obokata M, Olson TP, Reddy YNV, Melenovsky V, Kane GC, Borlaug BA.
Eur Heart J. 2018 Aug 7;39(30):2810-2821.
PMID: 29788047 Free PMC article.
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Resting and Exercise-Induced Left Atrial Hypertension in Patients With Atrial Fibrillation: The Causes and Implications for Catheter Ablation.
Sramko M, Wichterle D, Melenovsky V, Clemens M, Fukunaga M, Peichl P, Aldhoon B, Cihak R, Kautzner J.
JACC Clin Electrophysiol. 2017 May;3(5):461-469.
DOI: 10.1016/j.jacep.2016.12.010
PMID: 29759601 Free article.
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Isovolumic loading of the failing heart by intraventricular placement of a spring expander attenuates cardiac atrophy after heterotopic heart transplantation.
Pokorný M, Mrázová I, Šochman J, Melenovský V, Malý J, Pirk J, Červenková L, Sadowski J, Čermák Z, Volenec K, Vacková Š, Maxová H, Červenka L, Netuka I.
Biosci Rep. 2018 Jun 27;38(3):BSR20180371.
DOI: 10.1042/BSR20180371
PMID: 29743195 Free PMC article.
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Early detection of cardiac allograft vasculopathy using highly automated 3-dimensional optical coherence tomography analysis.
Pazdernik M, Chen Z, Bedanova H, Kautzner J, Melenovsky V, Karmazin V, Malek I, Tomasek A, Ozabalova E, Krejci J, Franekova J, Wahle A, Zhang H, Kovarnik T, Sonka M.
J Heart Lung Transplant. 2018 Aug;37(8):992-1000.
DOI: 10.1016/j.healun.2018.04.002
PMID: 29706574 Clinical Trial.
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Impact of Atrial Fibrillation on Natriuretic Peptides: An Invasive Atrial Hemodynamic Study.
Sramko M, Melenovsky V, Wichterle D, Franekova J, Clemens M, Kautzner J.
JACC Clin Electrophysiol. 2018 Jan;4(1):153-154.
DOI: 10.1016/j.jacep.2017.05.008
PMID: 29600782 Free article.
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Effect of angiotensin-converting enzyme blockade, alone or combined with blockade of soluble epoxide hydrolase, on the course of congestive heart failure and occurrence of renal dysfunction in Ren-2 transgenic hypertensive rats with aorto-caval fistula.
Kala P, Sedláková L, Škaroupková P, Kopkan L, Vaňourková Z, Táborský M, Nishiyama A, Hwang SH, Hammock BD, Sadowski J, Melenovský V, Imig JD, Červenka L.
Physiol Res. 2018 Jul 17;67(3):401-415.
DOI: 10.33549/physiolres.933757
PMID: 29527914 Free PMC article.
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Effects of increased myocardial tissue concentration of myristic, palmitic and palmitoleic acids on the course of cardiac atrophy of the failing heart unloaded by heterotopic transplantation.
Pokorný M, Mrázová I, Malý J, Pirk J, Netuka I, Vaňourková Z, Doleželová Š, Červenková L, Maxová H, Melenovský V, Šochman J, Sadowski J, Červenka L.
Physiol Res. 2018 Mar 16;67(1):13-30.
DOI: 10.33549/physiolres.933637
PMID: 29137478 Free article.
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A Complex Heart Team’s Approach to a Patient With Giant Cell Myocarditis.
Pazdernik M, Netuka I, Maly J, Kettner J, Voska L, Riha H, Pirk J, Melenovsky V, Kautzner J.
Can J Cardiol. 2017 Oct;33(10):1335.e5-1335.e7.
DOI: 10.1016/j.cjca.2017.05.027
PMID: 28822649
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Glucose Homeostasis, Pancreatic Endocrine Function, and Outcomes in Advanced Heart Failure.
Melenovsky V, Benes J, Franekova J, Kovar J, Borlaug BA, Segetova M, Tura A, Pelikanova T.
J Am Heart Assoc. 2017 Aug 7;6(8):e005290.
PMID: 28784650 Free PMC article.
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Arterial Stiffening With Exercise in Patients With Heart Failure and Preserved Ejection Fraction.
Reddy YNV, Andersen MJ, Obokata M, Koepp KE, Kane GC, Melenovsky V, Olson TP, Borlaug BA.
J Am Coll Cardiol. 2017 Jul 11;70(2):136-148.
DOI: 10.1016/j.jacc.2017.05.029
PMID: 28683960 Free PMC article. Clinical Trial.
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Value of Assessment of Exercise Hemodynamics in Patients With Atrial Fibrillation.
Sramko M, Wichterle D, Melenovsky V, Kautzner J.
J Card Fail. 2017 Aug;23(8):656.
DOI: 10.1016/j.cardfail.2017.05.014
PMID: 28552324 No abstract available.
-
Percutaneous Pericardial Resection: A Novel Potential Treatment for Heart Failure With Preserved Ejection Fraction.
Borlaug BA, Carter RE, Melenovsky V, DeSimone CV, Gaba P, Killu A, Naksuk N, Lerman L, Asirvatham SJ.
Circ Heart Fail. 2017 Apr;10(4):e003612.
DOI: 10.1161/CIRCHEARTFAILURE.116.003612
PMID: 28396500 Free PMC article.
-
Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction.
Obokata M, Reddy YNV, Pislaru SV, Melenovsky V, Borlaug BA.
Circulation. 2017 Jul 4;136(1):6-19.
DOI: 10.1161/CIRCULATIONAHA.116.026807
PMID: 28381470 Free PMC article.
-
Long-term Cardiovascular Changes Following Creation of Arteriovenous Fistula in Patients With End Stage Renal Disease.
Reddy YNV, Obokata M, Dean PG, Melenovsky V, Nath KA, Borlaug BA.
Eur Heart J. 2017 Jun 21;38(24):1913-1923.
PMID: 28329100
-
Clinical Correlates of B-Type Natriuretic Peptide Monitoring in Outpatients With Left Ventricular Assist Device.
Hegarova M, Kubanek M, Netuka I, Maly J, Dorazilova Z, Gazdic T, Franekova J, Lanska V, Melenovsky V, Kautzner J, Malek I.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017 Mar;161(1):68-74.
DOI: 10.5507/bp.2017.003
PMID: 28266662 Free article.
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Analysis of immune cell populations in atrial myocardium of patients with atrial fibrillation or sinus rhythm.
Smorodinova N, Bláha M, Melenovský V, Rozsívalová K, Přidal J, Ďurišová M, Pirk J, Kautzner J, Kučera T.
PLoS One. 2017 Feb 22;12(2):e0172691.
DOI: 10.1371/journal.pone.0172691
PMID: 28225836 Free PMC article.
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Aortic Waveform Analysis to Individualize Treatment in Heart Failure.
Wohlfahrt P, Melenovsky V, Redfield MM, Olson TP, Lin G, Abdelmoneim SS, Hametner B, Wassertheurer S, Borlaug BA.
Circ Heart Fail. 2017 Feb;10(2):e003516.
DOI: 10.1161/CIRCHEARTFAILURE.116.003516
PMID: 28159826 Free PMC article. Clinical Trial.
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Role of Diastolic Stress Testing in the Evaluation for Heart Failure With Preserved Ejection Fraction: A Simultaneous Invasive-Echocardiographic Study.
Obokata M, Kane GC, Reddy YN, Olson TP, Melenovsky V, Borlaug BA.
Circulation. 2017 Feb 28;135(9):825-838.
DOI: 10.1161/CIRCULATIONAHA.116.024822
PMID: 28039229 Free PMC article.
-
Reply to ‘Cardiac remodeling after reduction of high-flow arteriovenous fistulas in end-stage renal disease: methodological issues’.
Wohlfahrt P, Rokosny S, Melenovsky V, Borlaug BA, Pecenkova V, Balaz P.
Hypertens Res. 2017 Apr;40(4):411.
DOI: 10.1038/hr.2016.160
PMID: 27904157 No abstract available.
-
Heart rate response to exercise in heart failure patients: The prognostic role of metabolic-chronotropic relation and heart rate recovery.
Hajdusek P, Kotrc M, Kautzner J, Melenovsky V, Benesova E, Jarolim P, Benes J.
Int J Cardiol. 2017 Feb 1;228:588-593.
DOI: 10.1016/j.ijcard.2016.11.083
PMID: 27875738
-
Successful Treatment of Iron-Overload Cardiomyopathy in Hereditary Hemochromatosis With Deferoxamine and Deferiprone.
Tauchenová L, Křížová B, Kubánek M, Fraňková S, Melenovský V, Tintěra J, Kautznerová D, Malušková J, Jirsa M, Kautzner J.
Can J Cardiol. 2016 Dec;32(12):1574.e1-1574.e3.
DOI: 10.1016/j.cjca.2016.07.589
PMID: 27789107
-
Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis.
Melenovsky V, Petrak J, Mracek T, Benes J, Borlaug BA, Nuskova H, Pluhacek T, Spatenka J, Kovalcikova J, Drahota Z, Kautzner J, Pirk J, Houstek J.
Eur J Heart Fail. 2017 Apr;19(4):522-530.
DOI: 10.1002/ejhf.640
PMID: 27647766 Free article.
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Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload.
Sedmera D, Neckar J, Benes J Jr, Pospisilova J, Petrak J, Sedlacek K, Melenovsky V.
Front Physiol. 2016 Aug 25;7:367.
PMID: 27610087 Free PMC article.
-
B-type natriuretic peptide: powerful predictor of end-stage chronic heart failure in individuals with systolic dysfunction of the systemic right ventricle.
Hegarova M, Brotanek J, Kubanek M, Kockova R, Franekova J, Lanska V, Netuka I, Melenovsky V, Malek I, Kautzner J.
Croat Med J. 2016 Aug 31;57(4):343-50.
PMID: 27586549 Free PMC article.
-
High-Output Heart Failure: A 15-Year Experience.
Reddy YNV, Melenovsky V, Redfield MM, Nishimura RA, Borlaug BA.
J Am Coll Cardiol. 2016 Aug 2;68(5):473-482.
DOI: 10.1016/j.jacc.2016.05.043
PMID: 27470455 Free article.
-
Inhaled Sodium Nitrite Improves Rest and Exercise Hemodynamics in Heart Failure With Preserved Ejection Fraction.
Borlaug BA, Melenovsky V, Koepp KE.
Circ Res. 2016 Sep 16;119(7):880-6.
DOI: 10.1161/CIRCRESAHA.116.309184
PMID: 27458234 Free PMC article. Clinical Trial.
-
Abnormal right ventricular-pulmonary artery coupling with exercise in heart failure with preserved ejection fraction.
Borlaug BA, Kane GC, Melenovsky V, Olson TP.
Eur Heart J. 2016 Nov 14;37(43):3293-3302.
PMID: 27354047 Free PMC article.
-
Biphasic response in number of stem cells and endothelial progenitor cells after left ventricular assist device implantation: A 6-month follow-up.
Ivak P, Pitha J, Wohlfahrt P, Kralova Lesna I, Stavek P, Melenovsky V, Dorazilova Z, Hegarova M, Stepankova J, Maly J, Sekerkova A, Turcani D, Netuka I.
Int J Cardiol. 2016 Sep 1;218:98-103.
DOI: 10.1016/j.ijcard.2016.05.063
PMID: 27232919
-
Comparison of Cystatin C and NGAL in Early Diagnosis of Acute Kidney Injury After Heart Transplantation.
Hošková L, Franekova J, Málek I, Kautzner J, Szárszoi O, Jabor A, Pinďák M, Viklický O, Melenovský V.
Ann Transplant. 2016 May 26;21:329-245.
DOI: 10.12659/aot.896700
PMID: 27226081 Free article.
-
Cardiac remodeling after reduction of high-flow arteriovenous fistulas in end-stage renal disease.
Wohlfahrt P, Rokosny S, Melenovsky V, Borlaug BA, Pecenkova V, Balaz P.
Hypertens Res. 2016 Sep;39(9):654-9.
DOI: 10.1038/hr.2016.50
PMID: 27225601
-
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC).
Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, Falk V, González-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GMC, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P; ESC Scientific Document Group.
Eur Heart J. 2016 Jul 14;37(27):2129-2200.
PMID: 27206819 Free article.
-
Reply: Nitrites/Nitrates in Heart Failure With Preserved Ejection Fraction.
Borlaug BA, Koepp KE, Melenovsky V.
J Am Coll Cardiol. 2016 Mar 22;67(11):1383-4.
DOI: 10.1016/j.jacc.2015.12.055
PMID: 26988966 Free article. No abstract available.
-
Effect of Vericiguat, a Soluble Guanylate Cyclase Stimulator, on Natriuretic Peptide Levels in Patients With Worsening Chronic Heart Failure and Reduced Ejection Fraction: The SOCRATES-REDUCED Randomized Trial.
Gheorghiade M, Greene SJ, Butler J, Filippatos G, Lam CS, Maggioni AP, Ponikowski P, Shah SJ, Solomon SD, Kraigher-Krainer E, Samano ET, Müller K, Roessig L, Pieske B; SOCRATES-REDUCED Investigators and Coordinators.
JAMA. 2015 Dec 1;314(21):2251-62.
PMID: 26547357 Clinical Trial.
-
Lung congestion in chronic heart failure: haemodynamic, clinical, and prognostic implications.
Melenovsky V, Andersen MJ, Andress K, Reddy YN, Borlaug BA.
Eur J Heart Fail. 2015 Nov;17(11):1161-71.
DOI: 10.1002/ejhf.417
PMID: 26467180 Free article.
-
Association of Fibroblast Growth Factor-23 Levels and Angiotensin-Converting Enzyme Inhibition in Chronic Systolic Heart Failure.
Wohlfahrt P, Melenovsky V, Kotrc M, Benes J, Jabor A, Franekova J, Lemaire S, Kautzner J, Jarolim P.
JACC Heart Fail. 2015 Oct;3(10):829-39.
DOI: 10.1016/j.jchf.2015.05.012
PMID: 26450001 Free article.
-
Sodium Nitrite Improves Exercise Hemodynamics and Ventricular Performance in Heart Failure With Preserved Ejection Fraction.
Borlaug BA, Koepp KE, Melenovsky V.
J Am Coll Cardiol. 2015 Oct 13;66(15):1672-82.
DOI: 10.1016/j.jacc.2015.07.067
PMID: 26449137 Free article. Clinical Trial.
-
Novel insights into pretransplant allosensitization in heart transplant recipients in the contemporary era of immunosuppression and rejection surveillance.
Svobodova E, Gazdic T, Kubanek M, Vymetalova J, Voska L, Kment M, Lanska V, Kolesar L, Urban M, Netuka I, Pirk J, Melenovsky V, Kautzner J, Slavcev A, Malek I.
Transpl Int. 2016 Jan;29(1):63-72. Epub 2015 Sep 22.
DOI: 10.1111/tri.12684
PMID: 26340387 Free article.
-
Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.
Alánová P, Husková Z, Kopkan L, Sporková A, Jíchová Š, Neckář J, Imig JD, Klevstig M, Kolář F, Rami Reddy N, Falck JR, Sadowski J, Nishiyama A, Kramer HJ, Melenovský V, Červenková L, Kujal P, Vernerová Z, Červenka L.
Vascul Pharmacol. 2015 Oct;73:45-56. Epub 2015 Aug 22.
DOI: 10.1016/j.vph.2015.08.013
PMID: 26304700
-
Fully automated ultrasensitive digital immunoassay for cardiac troponin I based on single molecule array technology.
Jarolim P, Patel PP, Conrad MJ, Chang L, Melenovsky V, Wilson DH.
Clin Chem. 2015 Oct;61(10):1283-91. Epub 2015 Aug 17.
DOI: 10.1373/clinchem.2015.242081
PMID: 26283690
-
Bioptic Study of Left and Right Atrial Interstitium in Cardiac Patients with and without Atrial Fibrillation: Interatrial but Not Rhythm-Based Differences.
Smorodinova N, Lantová L, Bláha M, Melenovský V, Hanzelka J, Pirk J, Kautzner J, Kučera T.
PLoS One. 2015 Jun 12;10(6):e0129124.
DOI: 10.1371/journal.pone.0129124
PMID: 26067062 Free PMC article.
-
Inhibition of soluble epoxide hydrolase does not improve the course of congestive heart failure and the development of renal dysfunction in rats with volume overload induced by aorto-caval fistula.
Červenka L, Melenovský V, Husková Z, Sporková A, Bürgelová M, Škaroupková P, Hwang SH, Hammock BD, Imig JD, Sadowski J.
Physiol Res. 2015;64(6):857-73.
DOI: 10.33549/physiolres.932977
PMID: 26047375 Free PMC article.
-
Response to letter regarding “differential hemodynamic effects of exercise and volume expansion in people with and without heart failure”.
Andersen MJ, Olson TP, Melenovsky V, Kane GC, Borlaug BA.
Circ Heart Fail. 2015 Mar;8(2):411.
DOI: 10.1161/circheartfailure.115.002078
PMID: 25945379 No abstract available.
-
Enhanced pulmonary vasodilator reserve and abnormal right ventricular: pulmonary artery coupling in heart failure with preserved ejection fraction.
Andersen MJ, Hwang SJ, Kane GC, Melenovsky V, Olson TP, Fetterly K, Borlaug BA.
Circ Heart Fail. 2015 May;8(3):542-50. Epub 2015 Apr 9.
DOI: 10.1161/CIRCHEARTFAILURE.114.002114
PMID: 25857307 Clinical Trial.
-
Left atrial remodeling and function in advanced heart failure with preserved or reduced ejection fraction.
Melenovsky V, Hwang SJ, Redfield MM, Zakeri R, Lin G, Borlaug BA.
Circ Heart Fail. 2015 Mar;8(2):295-303. Epub 2015 Jan 15.
DOI: 10.1161/CIRCHEARTFAILURE.114.001667
PMID: 25593126
-
Impact of chronic changes in arterial compliance and resistance on left ventricular ageing in humans.
Wohlfahrt P, Redfield MM, Melenovsky V, Lopez-Jimenez F, Rodeheffer RJ, Borlaug BA.
Eur J Heart Fail. 2015 Jan;17(1):27-34. Epub 2014 Oct 31.
DOI: 10.1002/ejhf.190
PMID: 25359272 Free PMC article.
-
Differential hemodynamic effects of exercise and volume expansion in people with and without heart failure.
Andersen MJ, Olson TP, Melenovsky V, Kane GC, Borlaug BA.
Circ Heart Fail. 2015 Jan;8(1):41-8. Epub 2014 Oct 23.
DOI: 10.1161/CIRCHEARTFAILURE.114.001731
PMID: 25342738 Clinical Trial.
-
Impact of general and central adiposity on ventricular-arterial aging in women and men.
Wohlfahrt P, Redfield MM, Lopez-Jimenez F, Melenovsky V, Kane GC, Rodeheffer RJ, Borlaug BA.
JACC Heart Fail. 2014 Oct;2(5):489-99. Epub 2014 Sep 3.
DOI: 10.1016/j.jchf.2014.03.014
PMID: 25194285 Free PMC article.
-
Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES).
Pieske B, Butler J, Filippatos G, Lam C, Maggioni AP, Ponikowski P, Shah S, Solomon S, Kraigher-Krainer E, Samano ET, Scalise AV, Müller K, Roessig L, Gheorghiade M; SOCRATES Investigators and Coordinators.
Eur J Heart Fail. 2014 Sep;16(9):1026-38. Epub 2014 Jul 24.
DOI: 10.1002/ejhf.135
PMID: 25056511 Free article. Clinical Trial.
-
[30 years heart transplantation program in Institute for Clinical and Experimental Medicine in Prague].
Hošková L, Málek I, Melenovský V, Podzimková M, Hegarová M, Dorazilová Z, Kautzner J, Netuka I, Pirk J.
Vnitr Lek. 2014 Apr;60(4):275-81.
PMID: 24985984 Czech.
-
Right heart dysfunction in heart failure with preserved ejection fraction.
Melenovsky V, Hwang SJ, Lin G, Redfield MM, Borlaug BA.
Eur Heart J. 2014 Dec 21;35(48):3452-62. Epub 2014 May 29.
PMID: 24875795 Free PMC article.
-
Implications of coronary artery disease in heart failure with preserved ejection fraction.
Hwang SJ, Melenovsky V, Borlaug BA.
J Am Coll Cardiol. 2014 Jul 1;63(25 Pt A):2817-27. Epub 2014 Apr 23.
DOI: 10.1016/j.jacc.2014.03.034
PMID: 24768876 Free article.
-
A randomized pilot study of aortic waveform guided therapy in chronic heart failure.
Borlaug BA, Olson TP, Abdelmoneim SS, Melenovsky V, Sorrell VL, Noonan K, Lin G, Redfield MM.
J Am Heart Assoc. 2014 Mar 20;3(2):e000745.
PMID: 24650926 Free PMC article. Clinical Trial.
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Resting heart rate and heart rate reserve in advanced heart failure have distinct pathophysiologic correlates and prognostic impact: a prospective pilot study.
Benes J, Kotrc M, Borlaug BA, Lefflerova K, Jarolim P, Bendlova B, Jabor A, Kautzner J, Melenovsky V.
JACC Heart Fail. 2013 Jun;1(3):259-66. Epub 2013 Jun 3.
DOI: 10.1016/j.jchf.2013.03.008
PMID: 24621878 Free article.
-
Relationships between right ventricular function, body composition, and prognosis in advanced heart failure.
Melenovsky V, Kotrc M, Borlaug BA, Marek T, Kovar J, Malek I, Kautzner J.
J Am Coll Cardiol. 2013 Oct 29;62(18):1660-1670. Epub 2013 Jul 31.
DOI: 10.1016/j.jacc.2013.06.046
PMID: 23916933 Free article.
-
L-arginine in combination with sildenafil potentiates the attenuation of hypoxic pulmonary hypertension in rats.
Al-Hiti H, Chovanec M, Melenovský V, Vajnerová O, Baňasová A, Kautzner J, Herget J.
Physiol Res. 2013;62(6):589-95. Epub 2013 Jul 17.
DOI: 10.33549/physiolres.932463
PMID: 23869884 Free article.
-
Longitudinal changes in left ventricular stiffness: a community-based study.
Borlaug BA, Redfield MM, Melenovsky V, Kane GC, Karon BL, Jacobsen SJ, Rodeheffer RJ.
Circ Heart Fail. 2013 Sep 1;6(5):944-52. Epub 2013 Jun 28.
DOI: 10.1161/CIRCHEARTFAILURE.113.000383
PMID: 23811963 Free PMC article.
-
Assessment of optimal right ventricular pacing site using invasive measurement of left ventricular systolic and diastolic function.
Vancura V, Wichterle D, Melenovsky V, Kautzner J.
Europace. 2013 Oct;15(10):1482-90. Epub 2013 Apr 12.
PMID: 23585254
-
Associations between cardiac fibrosis and permanent atrial fibrillation in advanced heart failure.
Aldhoon B, Kučera T, Smorodinová N, Martínek J, Melenovský V, Kautzner J.
Physiol Res. 2013;62(3):247-55. Epub 2013 Mar 14.
DOI: 10.33549/physiolres.932409
PMID: 23489193 Free article.
-
Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction.
Abudiab MM, Redfield MM, Melenovsky V, Olson TP, Kass DA, Johnson BD, Borlaug BA.
Eur J Heart Fail. 2013 Jul;15(7):776-85. Epub 2013 Feb 20.
PMID: 23426022 Free PMC article.
-
The impact of left ventricle assist device on circulating endothelial microparticles – pilot study.
Pitha J, Dorazilova Z, Melenovsky V, Kralova Lesna I, Stavek P, Stepankova J, Urban M, Maly J, Netuka I.
Neuro Endocrinol Lett. 2012;33 Suppl 2:68-72.
PMID: 23183513 Clinical Trial.
-
The effects of phosphodiesterase 5 inhibition on hemodynamics, functional status and survival in advanced heart failure and pulmonary hypertension: a case-control study.
Reichenbach A, Al-Hiti H, Malek I, Pirk J, Goncalvesova E, Kautzner J, Melenovsky V.
Int J Cardiol. 2013 Sep 20;168(1):60-5. Epub 2012 Oct 8.
DOI: 10.1016/j.ijcard.2012.09.074
PMID: 23058346
-
Availability of energetic substrates and exercise performance in heart failure with or without diabetes.
Melenovsky V, Kotrc M, Polak J, Pelikanova T, Bendlova B, Cahova M, Malek I, Jarolim P, Kazdova L, Kautzner J.
Eur J Heart Fail. 2012 Jul;14(7):754-63. Epub 2012 Jun 12.
PMID: 22696515 Free article.
-
The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula.
Melenovsky V, Skaroupkova P, Benes J, Torresova V, Kopkan L, Cervenka L.
Kidney Blood Press Res. 2012;35(3):167-73. Epub 2011 Nov 24.
DOI: 10.1159/000331562
PMID: 22116309
-
Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aorto-caval fistula model provides support for new potential therapeutic targets – monoamine oxidase A and transglutaminase 2.
Petrak J, Pospisilova J, Sedinova M, Jedelsky P, Lorkova L, Vit O, Kolar M, Strnad H, Benes J, Sedmera D, Cervenka L, Melenovsky V.
Proteome Sci. 2011 Nov 11;9(1):69.
PMID: 22078724 Free PMC article.
-
Use of the Frank-Starling mechanism during exercise is linked to exercise-induced changes in arterial load.
Chantler PD, Melenovsky V, Schulman SP, Gerstenblith G, Becker LC, Ferrucci L, Fleg JL, Lakatta EG, Najjar SS.
Am J Physiol Heart Circ Physiol. 2012 Jan 1;302(1):H349-58. Epub 2011 Oct 14.
DOI: 10.1152/ajpheart.00147.2011
PMID: 22003052 Free PMC article.
-
Lipolytic effects of B-type natriuretic peptide 1-32 in adipose tissue of heart failure patients compared with healthy controls.
Polak J, Kotrc M, Wedellova Z, Jabor A, Malek I, Kautzner J, Kazdova L, Melenovsky V.
J Am Coll Cardiol. 2011 Sep 6;58(11):1119-25.
DOI: 10.1016/j.jacc.2011.05.042
PMID: 21884948 Free article.
-
Is severe pulmonary hypertension a contraindication for orthotopic heart transplantation? Not any more.
Kettner J, Dorazilová Z, Netuka I, Malý J, Al-Hiti H, Melenovský V, Skalský I, Říha H, Málek I, Kautzner J, Pirk J.
Physiol Res. 2011;60(5):769-75. Epub 2011 Aug 1.
DOI: 10.33549/physiolres.932158
PMID: 21812520 Free article.
-
Intermittent cardiogenic shock in a man with mechanical prosthesis of the aortic valve.
Melenovsky V, Al Hiti H, Lupinek P, Marek T, Veiser T, Skalsky I, Kettner J.
Circulation. 2011 Jul 5;124(1):e1-3.
DOI: 10.1161/CIRCULATIONAHA.110.012963
PMID: 21730310 No abstract available.
-
Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats.
Melenovsky V, Benes J, Skaroupkova P, Sedmera D, Strnad H, Kolar M, Vlcek C, Petrak J, Benes J Jr, Papousek F, Oliyarnyk O, Kazdova L, Cervenka L.
Mol Cell Biochem. 2011 Aug;354(1-2):83-96. Epub 2011 Apr 5.
DOI: 10.1007/s11010-011-0808-3
PMID: 21465236
-
Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats.
Benes J, Kazdova L, Drahota Z, Houstek J, Medrikova D, Kopecky J, Kovarova N, Vrbacky M, Sedmera D, Strnad H, Kolar M, Petrak J, Benada O, Skaroupkova P, Cervenka L, Melenovsky V.
Clin Sci (Lond). 2011 Jul;121(1):29-41.
DOI: 10.1042/CS20100527
PMID: 21275906
-
Myocardial morphological characteristics and proarrhythmic substrate in the rat model of heart failure due to chronic volume overload.
Benes J Jr, Melenovsky V, Skaroupkova P, Pospisilova J, Petrak J, Cervenka L, Sedmera D.
Anat Rec (Hoboken). 2011 Jan;294(1):102-11. Epub 2010 Nov 2.
DOI: 10.1002/ar.21280
PMID: 21157921 Free article.
-
Sildenafil is more selective pulmonary vasodilator than prostaglandin E1 in patients with pulmonary hypertension due to heart failure.
Al-Hiti H, Melenovský V, Syrovátka P, Kettner J, Málek I, Kautzner J.
Physiol Res. 2011;60(2):303-8. Epub 2010 Nov 29.
DOI: 10.33549/physiolres.931951
PMID: 21114369 Free article. Clinical Trial.
-
Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study.
Swedberg K, Komajda M, Böhm M, Borer JS, Ford I, Dubost-Brama A, Lerebours G, Tavazzi L; SHIFT Investigators.
Lancet. 2010 Sep 11;376(9744):875-85.
DOI: 10.1016/S0140-6736(10)61198-1
PMID: 20801500 Clinical Trial.
-
Life-threatening arrhythmia caused by primary aldosteronism.
Zelinka T, Holaj R, Petrák O, Strauch B, Kasalický M, Hanus T, Melenovský V, Vancura V, Bürgelová M, Widimský J Jr.
Med Sci Monit. 2009 Dec;15(12):CS174-7.
PMID: 19946238
-
Transpulmonary B-type natriuretic peptide uptake and cyclic guanosine monophosphate release in heart failure and pulmonary hypertension: the effects of sildenafil.
Melenovsky V, Al-Hiti H, Kazdova L, Jabor A, Syrovatka P, Malek I, Kettner J, Kautzner J.
J Am Coll Cardiol. 2009 Aug 11;54(7):595-600.
DOI: 10.1016/j.jacc.2009.05.021
PMID: 19660688 Free article.
-
New insights into mechanisms of atrial fibrillation.
Aldhoon B, Melenovský V, Peichl P, Kautzner J.
Physiol Res. 2010;59(1):1-12. Epub 2009 Feb 27.
DOI: 10.33549/physiolres.931651
PMID: 19249911 Free article. Review.
-
High basal metabolic rate is a risk factor for mortality: the Baltimore Longitudinal Study of Aging.
Ruggiero C, Metter EJ, Melenovsky V, Cherubini A, Najjar SS, Ble A, Senin U, Longo DL, Ferrucci L.
J Gerontol A Biol Sci Med Sci. 2008 Jul;63(7):698-706.
PMID: 18693224 Free PMC article.
-
Interleukin-8 and atrial fibrillation.
Melenovsky V, Lip GY.
Europace. 2008 Jul;10(7):784-5. Epub 2008 Jun 3.
PMID: 18523030 No abstract available.
-
The sex-specific impact of systolic hypertension and systolic blood pressure on arterial-ventricular coupling at rest and during exercise.
Chantler PD, Melenovsky V, Schulman SP, Gerstenblith G, Becker LC, Ferrucci L, Fleg JL, Lakatta EG, Najjar SS.
Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H145-53. Epub 2008 May 2.
DOI: 10.1152/ajpheart.01179.2007
PMID: 18456731 Free PMC article.
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Aortic dissection in a young man with Loeys-Dietz syndrome.
Melenovsky V, Adamira M, Kautznerova D, Voska L, Weichet J, Loeys B, Pirk J.
J Thorac Cardiovasc Surg. 2008 May;135(5):1174-5, 1175.e1.
DOI: 10.1016/j.jtcvs.2008.01.003
PMID: 18455604 Free article. No abstract available.
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Hyperlipidemia is associated with altered levels of insulin-like growth factor-I.
Malík J, Stulc T, Wichterle D, Melenovský V, Chytilová E, Lacinová Z, Marek J, Ceska R.
Physiol Res. 2008;57(6):919-925. Epub 2007 Nov 30.
DOI: 10.33549/physiolres.931281
PMID: 18052685 Free article.
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Impact of arterial load and loading sequence on left ventricular tissue velocities in humans.
Borlaug BA, Melenovsky V, Redfield MM, Kessler K, Chang HJ, Abraham TP, Kass DA.
J Am Coll Cardiol. 2007 Oct 16;50(16):1570-7. Epub 2007 Oct 1.
DOI: 10.1016/j.jacc.2007.07.032
PMID: 17936156 Free article.
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Estimation of central pressure augmentation using automated radial artery tonometry.
Melenovsky V, Borlaug BA, Fetics B, Kessler K, Shively L, Kass DA.
J Hypertens. 2007 Jul;25(7):1403-9.
DOI: 10.1097/HJH.0b013e32811d69df
PMID: 17563562
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Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension.
Zieman SJ, Melenovsky V, Clattenburg L, Corretti MC, Capriotti A, Gerstenblith G, Kass DA.
J Hypertens. 2007 Mar;25(3):577-83.
DOI: 10.1097/HJH.0b013e328013e7dd
PMID: 17278974 Clinical Trial.
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Cardiovascular features of heart failure with preserved ejection fraction versus nonfailing hypertensive left ventricular hypertrophy in the urban Baltimore community: the role of atrial remodeling/dysfunction.
Melenovsky V, Borlaug BA, Rosen B, Hay I, Ferruci L, Morell CH, Lakatta EG, Najjar SS, Kass DA.
J Am Coll Cardiol. 2007 Jan 16;49(2):198-207. Epub 2006 Dec 29.
DOI: 10.1016/j.jacc.2006.08.050
PMID: 17222731 Free article.
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Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction.
Borlaug BA, Melenovsky V, Russell SD, Kessler K, Pacak K, Becker LC, Kass DA.
Circulation. 2006 Nov 14;114(20):2138-47. Epub 2006 Nov 6.
DOI: 10.1161/CIRCULATIONAHA.106.632745
PMID: 17088459
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Hemodynamics and autonomic control of heart rate turbulence.
Wichterle D, Melenovsky V, Simek J, Malik J, Malik M.
J Cardiovasc Electrophysiol. 2006 Mar;17(3):286-91.
DOI: 10.1111/j.1540-8167.2005.00330.x
PMID: 16643402
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Sildenafil inhibits beta-adrenergic-stimulated cardiac contractility in humans.
Borlaug BA, Melenovsky V, Marhin T, Fitzgerald P, Kass DA.
Circulation. 2005 Oct 25;112(17):2642-9.
DOI: 10.1161/CIRCULATIONAHA.105.540500
PMID: 16246964 Clinical Trial.
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Relation between actual heart rate and autonomic effects of beta blockade in healthy men.
Melenovsky V, Simek J, Sperl M, Malik J, Wichterle D.
Am J Cardiol. 2005 Apr 15;95(8):999-1002.
DOI: 10.1016/j.amjcard.2004.12.048
PMID: 15820176 Clinical Trial.
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Pulse wave analysis during supine rest may identify subjects with recurrent vasovagal syncope.
Simek J, Wichterle D, Melenovsky V, Malik J, Svobodova J, Svacina S.
Clin Sci (Lond). 2005 Aug;109(2):165-70.
DOI: 10.1042/CS20040304
PMID: 15740456
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Mechanisms, pathophysiology, and therapy of arterial stiffness.
Zieman SJ, Melenovsky V, Kass DA.
Arterioscler Thromb Vasc Biol. 2005 May;25(5):932-43. Epub 2005 Feb 24.
DOI: 10.1161/01.ATV.0000160548.78317.29
PMID: 15731494 Review.
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Second derivative of the finger arterial pressure waveform: an insight into dynamics of the peripheral arterial pressure pulse.
Simek J, Wichterle D, Melenovský V, Malík J, Svacina S, Widimský J.
Physiol Res. 2005;54(5):505-13. Epub 2005 Jan 10.
DOI: 10.33549/physiolres.931951
PMID: 15641931 Free article. Clinical Trial.
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Functional impact of rate irregularity in patients with heart failure and atrial fibrillation receiving cardiac resynchronization therapy.
Melenovsky V, Hay I, Fetics BJ, Borlaug BA, Kramer A, Pastore JM, Berger R, Kass DA.
Eur Heart J. 2005 Apr;26(7):705-11. Epub 2004 Dec 20.
PMID: 15618039
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Short-term effects of right-left heart sequential cardiac resynchronization in patients with heart failure, chronic atrial fibrillation, and atrioventricular nodal block.
Hay I, Melenovsky V, Fetics BJ, Judge DP, Kramer A, Spinelli J, Reister C, Kass DA, Berger RD.
Circulation. 2004 Nov 30;110(22):3404-10. Epub 2004 Nov 22.
DOI: 10.1161/01.CIR.0000148177.82319.C7
PMID: 15557370
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Repeatability of noninvasive surrogates of endothelial function.
Malik J, Wichterle D, Haas T, Melenovsky V, Simek J, Stulc T.
Am J Cardiol. 2004 Sep 1;94(5):693-6.
DOI: 10.1016/j.amjcard.2004.05.049
PMID: 15342316
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Effect of atorvastatin and fenofibrate on autonomic tone in subjects with combined hyperlipidemia.
Melenovsky V, Wichterle D, Simek J, Malik J, Haas T, Ceska R, Malik M.
Am J Cardiol. 2003 Aug 1;92(3):337-41.
DOI: 10.1016/s0002-9149(03)00643-x
PMID: 12888150 Clinical Trial.
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Effect of folic acid on fenofibrate-induced elevation of homocysteine and cysteine.
Melenovsky V, Stulc T, Kozich V, Grauova B, Krijt J, Wichterle D, Haas T, Malik J, Hradec J, Ceska R.
Am Heart J. 2003 Jul;146(1):110.
DOI: 10.1016/S0002-8703(03)00122-4
PMID: 12851616 Clinical Trial.
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[Heart rate turbulence–a new ECG predictor for risk of sudden death].
Melenovský V, Wichterle D, Simek J, Malík J.
Vnitr Lek. 2002 Dec;48 Suppl 1:150-4.
PMID: 12744038 Czech.
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Comparison of the effects of atorvastatin or fenofibrate on nonlipid biochemical risk factors and the LDL particle size in subjects with combined hyperlipidemia.
Melenovsky V, Malik J, Wichterle D, Simek J, Pisarikova A, Skrha J, Poledne R, Stavek P, Ceska R.
Am Heart J. 2002 Oct;144(4):E6.
DOI: 10.1016/s0002-8703(02)00142-4
PMID: 12360175 Clinical Trial.
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Mechanisms involved in heart rate turbulence.
Wichterle D, Melenovsky V, Malik M.
Card Electrophysiol Rev. 2002 Sep;6(3):262-6.
PMID: 12114849 Review.
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Nitroglycerin induced syncope occurs in subjects with delayed phase shift of baroreflex action.
Melenovsky V, Wichterle D, Malik J, Simek J, Hradec J, Ceska R, Malik M.
Pacing Clin Electrophysiol. 2002 May;25(5):828-32.
DOI: 10.1046/j.1460-9592.2002.t01-1-00828.x
PMID: 12049376
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The changes of IGF binding proteins after rhGH administration to patients totally dependent on parenteral nutrition.
Justová V, Lacinová Z, Melenovský V, Marek J, Holly JM, Hass T.
Growth Horm IGF Res. 2001 Dec;11(6):407-15.
PMID: 11914029 Clinical Trial.
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Both fenofibrate and atorvastatin improve vascular reactivity in combined hyperlipidaemia (fenofibrate versus atorvastatin trial–FAT).
Malik J, Melenovsky V, Wichterle D, Haas T, Simek J, Ceska R, Hradec J.
Cardiovasc Res. 2001 Nov;52(2):290-8.
DOI: 10.1016/s0008-6363(01)00382-0
PMID: 11684077 Clinical Trial.
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Folate supplementation prevents plasma homocysteine increase after fenofibrate therapy.
Stulc T, Melenovský V, Grauová B, Kozich V, Ceska R.
Nutrition. 2001 Sep;17(9):721-3.
DOI: 10.1016/s0899-9007(01)00612-8
PMID: 11527658 Clinical Trial.
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Cross-spectral analysis of heart rate and blood pressure modulations.
Wichterle D, Melenovský V, Simek J, Necasová L, Kautzner J, Malík M.
Pacing Clin Electrophysiol. 2000 Sep;23(9):1425-30.
DOI: 10.1111/j.1540-8159.2000.tb00974.x
PMID: 11025902
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[Function and dysfunction of the endothelium].
Malík J, Melenovský V, Wichterle D.
Cas Lek Cesk. 2000 Apr 12;139(7):197-202.
PMID: 10916205 Review. Czech.
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Stability of the noninvasive baroreflex sensitivity assessment using cross-spectral analysis of heart rate and arterial blood pressure variabilities.
Wichterle D, Melenovsky V, Necasova L, Kautzner J, Malik M.
Clin Cardiol. 2000 Mar;23(3):201-4.
PMID: 10761809 Free PMC article.
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Penetration of antibiotics into the pancreas in rats: an effect of acute necrotizing pancreatitis.
Spicák J, Martínek J, Závada F, Morávek J, Melenovsky V.
Scand J Gastroenterol. 1999 Jan;34(1):92-7.
DOI: 10.1080/00365529950172899
PMID: 10048739